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HEALTH TIP: The 5 Symptoms of a Heart Attack: Do You Know Them?
I have to admit when I read an article (in Shape Magazine)
that 69 percent of all people don’t know all five of the
classic heart attack symptoms, I was pretty surprised.

That is, until I realized I didn’t know them all… uh-oh!

With heart disease affecting more people, it’s rising among
younger people and women, not to mention those you’d “expect”
to be stricken, it’s important for all of us to learn real
quick what these telltale signs are. Do you know them?

1. Pain or pressure in the chest

2. Shortness of breath

3. Pulsating pain in the jaw, neck or back

4. Feelings of weakness or light-headedness

5. Radiating pain in the arms or shoulders

So… did you know them or just a few? Try to keep these in mind.
But most importantly… regardless of how resilient and invincible
you believe you are, if you find yourself experiencing any of these
symptoms, give your doc (or emergency personnel) a call in a hurry.
$4M Grant Aids Healthcare Reform Study…

STATE COLLEGE, Pa., — Pennsylvania State University has
received a three-year, $4 million grant to expand its eval-
uation of a health quality reform project. Associate Pro-
fessor Dennis Scanlon will use the Robert Wood Johnson Foun-
dation funding to evaluate that organization’s national
initiative “Aligning Forces for Quality,” or AF4Q. The grant
is in addition to last year’s original $3.4 million award
from the foundation. “AF4Q aims to bring together patients,
healthcare providers and payers to turn proven practices for
improving (healthcare) quality into real results,” Penn
State said in a statement. “Through regional collaboratives,
it aims to lift the overall quality of health, reduce racial
disparities and provide models for national reform.” The
$300 million initiative involves 14 community-based programs
across the United States in which teams help physicians
improve their quality of care and give consumers information
that helps them manage their health and in making informed
choices about their healthcare. The community alliances will
also work to improve care inside hospitals, with a special
focus on nursing and on reducing inequality in care for pat-
ients of different races and ethnicities. Scanlon and his
colleagues will evaluate the impact of the program in the 14
communities.
FDA: Food Protection Plan Shows Progress…

WASHINGTON,  — The U.S. Food and Drug Administration
says its plan to keep U.S. citizens enjoying one of
the safest food supplies in the world shows significant
progress. The FDA said its Food Protection Plan Progress
Report, released Wednesday, shows significant areas of act-
ivity in its efforts to address domestic and global changes
in food supply. “The Food Protection Plan is the comprehen-
sive framework the agency needs to enhance the protection
of our nation’s food supply,” said FDA Commissioner Andrew
von Eschenbach. “Implementing the strategic approaches out-
lined in the plan is essential if we are to enhance our
ability to respond and intervene in foodborne outbreaks.”
The progress report is available at…
www.fda.gov/oc/initiatives/advance/food/progressreport.html

An Alzheimer’s Disease Target Identified…

PHILADELPHIA,– U.S. scientists say the protein neprilysin
can reduce plaque formation and neuron death associated with
Alzheimer’s disease, but at the expense of lifespan. Thomas
Jefferson University researchers said the buildup of amyloid-
beta protein plaques within the brain is a hallmark of Alz-
heimer’s. Normally, enzymes remove the plaques, and defici-
encies in those enzymes are one potential disease cause. The
scientists said neprilysin, or NEP, a major amyloid degrad-
er, decreases naturally with age and might be the reason the
elderly are more at risk for Alzheimer’s. While studies
using mice suggest enhancing NEP production has potential,
the possible adverse effects of such therapy were unknown.
The new research with transgenic fruit flies expressing
human NEP found a “good news-bad news” scenario. On the pos-
itive side, NEP expression did reduce plaque deposits and
neuron damage in the flies. On the other hand, NEP also
reduced the activity of important neural proteins called
CREB proteins and shortened the flies’ average lifespan. The
researchers said their finding illustrates caution is need-
ed when considering Alzheimer’s treatments, and that it’s
critical to better understand normal aging when dealing with
Alzheimer’s or other age-related conditions. The study
appears online in the Journal of Biological Chemistry.
        

Scientist Hones Cancer Therapy Strategies…
TALLAHASSEE, Fla., — A U.S. scientist says he’s using high-
powered computers to create cancer treatments involving a
new class of tumor-killing drugs. Florida State University
Assistant Professor Kevin Chen says he wants to determine
how substances known as recombinant immunotoxins can best be
modified to attack and kill malignant tumors while doing
minimal harm to a patient’s healthy cells. “Cancer is a
disease of tremendous complexity, so the analysis and inter-
pretation of data demands sophisticated, specialized compu-
tational methods,” Chen said. He said recombinant immunotox-
ins are new drugs consisting of tiny fragments of antibody
proteins that are fused at the genetic level to toxins pro-
duced by certain types of bacteria, fungi or plants. “Once
injected into the body, the antibody portion of the immuno-
toxin targets specific proteins called antigens that are
massively expressed on the surface of cancer cells,” Chen
said. “These cells are subsequently killed by the accom-
panying toxins. Normal, healthy cells, meanwhile, are not
recognized and thus are spared.” The study that included
FSU researchers Junho Kim and Xinmei Li and molecular bio-
logist Byungkook Lee of the National Cancer Institute in
Bethesda, Md., appeared in the March issue of the journal
Annals of Biomedical Engineering.
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